DiseaseID 3836
干眼病
disease
MSH2017_2016_08_12:Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.|HPO2016_07_04:Dr
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Disease: 1Symptom: 7Target: 12Links: 19
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Record Fields
Scalar fields from the final disease record.
- Disease Id
- 3836
- Core Entity Id
- 60092
- Source Entity Count
- 1
- Preferred Name
- Xerophthalmia
- Name Cn
- 干眼病
- Name Pinyin
- Gan Yan Bing
- Name En
- Xerophthalmia
- Name Latin
- Bilingual Status
- complete
- Disease Type
- disease
- Umls Disease Type
- Disease or Syndrome
- Disgenet Type
- disease
- Mesh Class
- Eye Diseases
- Do Class
- disease of anatomical entity
- Hpo Class
- Abnormality of head or neck; Abnormality of the immune system; Abnormality of the eye; Abnormality of the cardiovascular system
- Mesh Class Name
- Eye Diseases
- Hpo Class Name
- Abnormality of the immune system; Abnormality of head or neck; Abnormality of the eye; Abnormality of the cardiovascular system
- Do Class Name
- disease of anatomical entity
- Disease Definition
- MSH2017_2016_08_12:Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.|HPO2016_07_04:Dryness of the eye related to deficiency of the tear film components (aqueous, mucin, or lipid), lid surface abnormalities, or epithelial abnormalities. Keratoconjunctivitis sicca often results in a scratchy or sandy sensation (foreign body sensation) in the eyes, and may also be associated with itching, inability to produce tears, photosensitivity, redness, pain, and difficulty in moving the eyelids. [HPO:probinson]|CSP2006:drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion.|AIR93:WHAT: Keratoconjunctivitis sicca. Keratoconjunctivitis Sicca (KCS): an eye condition in which there is decreased tear production and inflammation of the cornea and conjunctiva. WHY: Keratoconjunctivitis sicca is found in a significant number of patients with rheumatoid arthritis. KCS has also been described in systemic lupus erythematosus, polyarteritis nodosa, and scleroderma. KCS plus xerostomia is called the sicca syndrome. The association of the sicca syndrome with rheumatoid arthritis is known as Sjogren's syndrome. HOW: Clinically, patients with KCS may present with itching, burning eyes. They may complain of a dry sensation or of a foreign body sensation of the eyes. The conjunctiva is hyperemic, and thick strands of mucus may cover the eye. With slit lamp examination there is less than 1 mm of tear width at the margins of the upper and lower lids. There is increased debris and mucus strands within the tear film, seen best after blinking. Tiny punctate opacities are seen throughout the corneal surface. The Schirmer tear test (which is most accurately performed without topical anesthesia) shows less than 5 mm of wetting of filter paper at the end of 5 minutes. Finally, rose bengal, which is a water soluble dye specific for devitalized cells and mucin, will stain the dessicated corneal and conjunctival cells a bright red color. REFS: 1) Henkind, P and Gold, DH: Ocular manifestations of rheumatic disorders. Rheumatology 4:13, 1973. 2) Havener, W: Synopsis of ophthamology. St. Louis, C.V. Mosby Company, 1979. 3) Anderson, JR; Whaley, K; Williams, J and Buchanan, WW: A statistical aid to the diagnosis of keratoconjunctivitis sicca. Quart J Med 41:175, 1972. DN19292-9.
- Version
- v2
- Suppressed
- No
Names
Preferred names, aliases, and source labels retained in the final schema.
Name
Xerophthalmia
Role
preferred
Name
Dry Eye Syndromes
Role
preferred
Name
Keratoconjunctivitis Sicca
Role
preferred
Name
Dry Eye Syndrome
Role
alias
Name
Dry Eyes
Role
alias
Cross References
Trusted external identifiers retained for this final record.
Herb
HBDIS000830HBDIS001601HBDIS003160
Me Sh
D007638D015352
Umls
C0013238C0022575
Sym Map
SMDE08045SMDE10179SMDE14410
Do Class
DOID:7
Dis Ge Net
C0013238C0022575C0043349
Umls Sty
T047
Hpo Class
HP:0000152HP:0000478HP:0001626HP:0002715
Me Sh Class
C11
Tcmbank Disease
12530160382255831061
Itcmdb Generated
ITX-DISEASE-13440DA23C2F
Attributes
Merged source attributes and domain-specific metadata.
Version
v2
Suppress
0
Do Class Name
disease of anatomical entity
Disease Type
disease
Hpo Class Name
Abnormality of the immune system; Abnormality of head or neck; Abnormality of the eye; Abnormality of the cardiovascular system
Do Disease Class
disease of anatomical entity
Hpo Disease Class
Abnormality of head or neck; Abnormality of the immune system; Abnormality of the eye; Abnormality of the cardiovascular system
Umls Disease Type
Disease or Syndrome
Disease Definition
MSH2017_2016_08_12:Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.|HPO2016_07_04:Dryness of the eye related to deficiency of the tear film components (aqueous, mucin, or lipid), lid surface abnormalities, or epithelial abnormalities. Keratoconjunctivitis sicca often results in a scratchy or sandy sensation (foreign body sensation) in the eyes, and may also be associated with itching, inability to produce tears, photosensitivity, redness, pain, and difficulty in moving the eyelids. [HPO:probinson]|CSP2006:drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion.|AIR93:WHAT: Keratoconjunctivitis sicca. Keratoconjunctivitis Sicca (KCS): an eye condition in which there is decreased tear production and inflammation of the cornea and conjunctiva. WHY: Keratoconjunctivitis sicca is found in a significant number of patients with rheumatoid arthritis. KCS has also been described in systemic lupus erythematosus, polyarteritis nodosa, and scleroderma. KCS plus xerostomia is called the sicca syndrome. The association of the sicca syndrome with rheumatoid arthritis is known as Sjogren's syndrome. HOW: Clinically, patients with KCS may present with itching, burning eyes. They may complain of a dry sensation or of a foreign body sensation of the eyes. The conjunctiva is hyperemic, and thick strands of mucus may cover the eye. With slit lamp examination there is less than 1 mm of tear width at the margins of the upper and lower lids. There is increased debris and mucus strands within the tear film, seen best after blinking. Tiny punctate opacities are seen throughout the corneal surface. The Schirmer tear test (which is most accurately performed without topical anesthesia) shows less than 5 mm of wetting of filter paper at the end of 5 minutes. Finally, rose bengal, which is a water soluble dye specific for devitalized cells and mucin, will stain the dessicated corneal and conjunctival cells a bright red color. REFS: 1) Henkind, P and Gold, DH: Ocular manifestations of rheumatic disorders. Rheumatology 4:13, 1973. 2) Havener, W: Synopsis of ophthamology. St. Louis, C.V. Mosby Company, 1979. 3) Anderson, JR; Whaley, K; Williams, J and Buchanan, WW: A statistical aid to the diagnosis of keratoconjunctivitis sicca. Quart J Med 41:175, 1972. DN19292-9.NCI2016_02D:Dryness of the eye due to inadequate production of tears. Causes include vitamin A deficiency, Sjogren syndrome, rheumatoid arthritis, systemic lupus erythematosus, and scleroderma.|MSH2017_2016_08_12:Dryness of the eye surfaces caused by deficiency of tears or conjunctival secretions. It may be associated with vitamin A deficiency, trauma, or any condition in which the eyelids do not close completely.|CSP2006:dryness of the eye surfaces caused by deficiency of tears or conjunctival secretions; may be associated with vitamin A deficiency, trauma, or any condition in which the eyelids do not close completely.NCI2016_NICHD_1602D:Breakdown of the tear film, resulting in decreased lubrication of the cornea and/or conjunctiva.|NCI2016_CTCAE_1602D:A disorder characterized by dryness of the cornea and conjunctiva.|NCI2016_02D:A syndrome characterized by dryness of the cornea and conjunctiva. It is usually caused by a deficiency in tear production. Symptoms include a feeling of burning eyes and a possible foreign body presence in the eye.|MSH2017_2016_08_12:Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
Me Sh Disease Class
Eye Diseases
Dis Ge Net Disease Type
disease
Disease Class Name Me Sh
Eye Diseases
Umls Semantic Type Name
Disease or Syndrome