DiseaseID 30715
施瓦茨曼反应
Schwartzman Reaction
MSH2017_2016_08_12:Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a
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Disease: 1Symptom: 2Target: 12Links: 14
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Record Fields
Scalar fields from the final disease record.
- Disease Id
- 30715
- Core Entity Id
- 123283
- Source Entity Count
- 1
- Preferred Name
- Schwartzman Reaction
- Name Cn
- 施瓦茨曼反应
- Name Pinyin
- Shi Wa Ci Man Fan Ying
- Name En
- Schwartzman Reaction
- Name Latin
- Bilingual Status
- complete
- Disease Type
- Umls Disease Type
- Disgenet Type
- Mesh Class
- Do Class
- Hpo Class
- Mesh Class Name
- Hpo Class Name
- Do Class Name
- Disease Definition
- MSH2017_2016_08_12:Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.|CSP2006:vasculitis, local or systemic, caused by a two-stage reaction in which a first encounter with endotoxin produces intravascular fibrin thrombi whose clearance results in reticuloendothelial blockade which prevents the clearance of thrombi caused by a second encounter with endotoxin, (or a variety of polyanions, glycogen or antigen/antibody complexes) resulting in tissue necrosis and/or hemorrhage; in pregnancy gram-negative septicemia during delivery or abortion may serve as the first or provocative encounter.
- Version
- v2
- Suppressed
- No
Names
Preferred names, aliases, and source labels retained in the final schema.
Name
Schwartzman Reaction
Role
preferred
Source
SymMap_v2
Preferred
Yes
Cross References
Trusted external identifiers retained for this final record.
Umls
C0037018
Sym Map
SMDE12988
Attributes
Merged source attributes and domain-specific metadata.
Version
v2
Suppress
0
Disease Definition
MSH2017_2016_08_12:Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.|CSP2006:vasculitis, local or systemic, caused by a two-stage reaction in which a first encounter with endotoxin produces intravascular fibrin thrombi whose clearance results in reticuloendothelial blockade which prevents the clearance of thrombi caused by a second encounter with endotoxin, (or a variety of polyanions, glycogen or antigen/antibody complexes) resulting in tissue necrosis and/or hemorrhage; in pregnancy gram-negative septicemia during delivery or abortion may serve as the first or provocative encounter.