DiseaseID 17108

骨髓增生异常综合征

group

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Disease: 1Experiment: 7Herb: 1Symptom: 12Target: 24Links: 44

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Record Fields

Scalar fields from the final disease record.

Disease Id: 17108
Core Entity Id: 75282
Source Entity Count: 1
Preferred Name: Myelodysplastic Syndrome
Name Cn: 骨髓增生异常综合征
Name Pinyin: Gu Sui Zeng Sheng Yi Chang Zong He Zheng
Name En: Myelodysplastic Syndrome
Name Latin
Bilingual Status: complete
Disease Type: group
Umls Disease Type: Neoplastic Process
Disgenet Type: group
Mesh Class: Hemic and Lymphatic Diseases
Do Class: disease of anatomical entity; disease of cellular proliferation
Hpo Class: Abnormality of blood and blood-forming tissues; Neoplasm
Mesh Class Name: Hemic and Lymphatic Diseases
Hpo Class Name: Neoplasm; Abnormality of blood and blood-forming tissues
Do Class Name: disease of anatomical entity; disease of cellular proliferation
Disease Definition: NCI2016_NICHD_1602D:A pre-malignant disorder characterized by blood cytopenias and abnormalities in bone marrow morphology.|NCI2016_NCI-GLOSS_1602D:A group of diseases in which the bone marrow does not make enough healthy blood cells.|NCI2016_CTCAE_1602D:A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow.|NCI2016_02D:A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)|MSH2017_2016_08_12:Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.|MEDLINEPLUS_20151021:Your <a href='https://www.nlm.nih.gov/medlineplus/bonemarrowdiseases.html'>bone marrow</a> is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. If you have a myelodysplastic syndrome, the stem cells do not mature into healthy blood cells. Many of them die in the bone marrow. This means that you do not have enough healthy cells, which can lead to infection, <a href='https://www.nlm.nih.gov/medlineplus/anemia.html'>anemia</a>, or easy bleeding. Myelodysplastic syndromes often do not cause early symptoms and are sometimes found during a routine blood test. If you have symptoms, they may include <ul> <li>Shortness of breath</li> <li>Weakness or feeling tired</li> <li>Skin that is paler than usual</li> <li>Easy bruising or bleeding</li> <li>Pinpoint spots under the skin caused by bleeding</li> <li>Fever or frequent infections</li> </ul> Myelodysplastic syndromes are rare. People at higher risk are over 60, have had chemotherapy or radiation therapy, or have been exposed to certain chemicals. Treatment options include transfusions, drug therapy, chemotherapy, and blood or bone marrow stem cell transplants. NIH: National Cancer Institute|HPO2016_07_04:Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia. [HPO:probinson]
Version: v1,v2
Suppressed: No

Names

Preferred names, aliases, and source labels retained in the final schema.

Name

Myelodysplastic Syndrome

Role

preferred

Name

Hematopoetic Myelodysplasia

Role

preferred

Name

MDS

Role

alias

Name

MYELODYSPLASTIC SYNDROME, SUSCEPTIBILITY TO

Role

alias

Name

Myelodysplasia

Role

alias

Name

Myelodysplastic Syndrome, Unspecified

Role

alias

Name

Myelodysplastic Syndromes

Role

alias

Name

Syndrome, Myelodysplastic

Role

alias

Cross References

Trusted external identifiers retained for this final record.

Hpo

HP:0002863

Herb

HBDIS019656HBDIS021400

Me Sh

D009190

Omim

614286

Umls

C3463824

Icd10

D46D46.9

Sym Map

SMDE03250

Do Class

DOID:14566DOID:7

Dis Ge Net

C2713368C3463824

Umls Sty

T046T191

Hpo Class

HP:0001871HP:0002664

Me Sh Class

C15

Etcm Disease

Myelodysplastic Syndrome

Tcmbank Disease

1349521578

Itcmdb Generated

ITX-DISEASE-F69FDEA34AF5

Attributes

Merged source attributes and domain-specific metadata.

Version

v1,v2

Suppress

Page Title

Disease Myelodysplastic Syndrome Details page

Do Class Name

disease of anatomical entity; disease of cellular proliferation

Disease Type

groupphenotype

Hpo Class Name

Neoplasm; Abnormality of blood and blood-forming tissues

Do Disease Class

disease of anatomical entity; disease of cellular proliferation

Hpo Disease Class

Abnormality of blood and blood-forming tissues; Neoplasm

Umls Disease Type

Neoplastic ProcessPathologic Function

Basic Information

Disease Name

Myelodysplastic Syndrome

Global Category

Genetic diseases;Rare diseases

Anatomical Category

Blood diseases

Disease Definition

NCI2016_NICHD_1602D:A pre-malignant disorder characterized by blood cytopenias and abnormalities in bone marrow morphology.|NCI2016_NCI-GLOSS_1602D:A group of diseases in which the bone marrow does not make enough healthy blood cells.|NCI2016_CTCAE_1602D:A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow.|NCI2016_02D:A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)|MSH2017_2016_08_12:Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.|MEDLINEPLUS_20151021:Your <a href='https://www.nlm.nih.gov/medlineplus/bonemarrowdiseases.html'>bone marrow</a> is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. If you have a myelodysplastic syndrome, the stem cells do not mature into healthy blood cells. Many of them die in the bone marrow. This means that you do not have enough healthy cells, which can lead to infection, <a href='https://www.nlm.nih.gov/medlineplus/anemia.html'>anemia</a>, or easy bleeding. Myelodysplastic syndromes often do not cause early symptoms and are sometimes found during a routine blood test. If you have symptoms, they may include <ul> <li>Shortness of breath</li> <li>Weakness or feeling tired</li> <li>Skin that is paler than usual</li> <li>Easy bruising or bleeding</li> <li>Pinpoint spots under the skin caused by bleeding</li> <li>Fever or frequent infections</li> </ul> Myelodysplastic syndromes are rare. People at higher risk are over 60, have had chemotherapy or radiation therapy, or have been exposed to certain chemicals. Treatment options include transfusions, drug therapy, chemotherapy, and blood or bone marrow stem cell transplants. NIH: National Cancer Institute|HPO2016_07_04:Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia. [HPO:probinson]

Me Sh Disease Class

Hemic and Lymphatic Diseases

Dis Ge Net Disease Type

groupphenotype

Disease Class Name Me Sh

Hemic and Lymphatic Diseases

Umls Semantic Type Name

Neoplastic ProcessPathologic Function