DiseaseID 1282

淋巴瘤

disease

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Disease: 1Formula: 5Herb: 2Symptom: 12Target: 23Links: 43

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Record Fields

Scalar fields from the final disease record.

Disease Id: 1282
Core Entity Id: 1447
Source Entity Count: 1
Preferred Name: Lymphoma
Name Cn: 淋巴瘤
Name Pinyin: Lin Ba Liu
Name En: Lymphoma
Name Latin
Bilingual Status: complete
Disease Type: disease
Umls Disease Type: Disease or Syndrome
Disgenet Type: disease
Mesh Class: Cardiovascular Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Nutritional and Metabolic Diseases; Immune System DiseasesFemale Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; NeoplasmsImmune System Diseases; Infections; Neoplasms; Hemic and Lymphatic DiseasesImmune System Diseases; Neoplasms; Hemic and Lymphatic DiseasesNervous System Diseases; Immune System Diseases; Neoplasms; Hemic and Lymphatic Diseases
Do Class: disease of anatomical entity; disease of cellular proliferationdisease of anatomical entity; genetic disease
Hpo Class: Abnormality of blood and blood-forming tissues; NeoplasmNeoplasm; Abnormality of the genitourinary system
Mesh Class Name: Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular DiseasesNeoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital DiseasesNeoplasms; Immune System Diseases; Hemic and Lymphatic DiseasesNeoplasms; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic DiseasesNeoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
Hpo Class Name: Abnormality of the genitourinary system; NeoplasmNeoplasm; Abnormality of blood and blood-forming tissues
Do Class Name: disease of anatomical entity; disease of cellular proliferationgenetic disease; disease of anatomical entity
Disease Definition: Ataxia with oculomotor apraxia type 1 (AOA1) is a rare autosomal recessive cerebellar ataxia (ARCA; see this term), characterized by progressive cerebellar ataxia associated with oculomotor apraxia, s
Version: v1
Suppressed: No

Names

Preferred names, aliases, and source labels retained in the final schema.

Name

Lymphoma

Role

preferred

Name

Ataxia-Telangiectasia

Role

preferred

Name

Ataxia-Telangiectasia Variant

Role

preferred

Name

Atm Gene

Role

preferred

Name

B-Cell Lymphomas

Role

preferred

Name

Burkitt Lymphoma

Role

preferred

Name

Kidney Neoplasm

Role

preferred

Name

Lymphoma, Non-Hodgkin, Familial

Role

preferred

Name

Lymphoma, Small Noncleaved-Cell

Role

preferred

Name

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Role

preferred

Name

Mantle Cell Lymphoma

Role

preferred

Name

African Burkitt'S Lymphoma

Role

preferred

Name

Ataxia Telangiectasia

Role

preferred

Name

Ataxia-Oculomotor Apraxia Type 1

Role

preferred

Name

Atypical Burkitt'S Lymphoma

Role

preferred

Name

Burkitt Leukemia

Role

preferred

Name

Burkitt-Like Lymphoma

Role

preferred

Name

Diffuse Mixed-Cell Lymphoma

Role

preferred

Name

High Grade Lymphoma (Neoplasm)

Role

preferred

Name

Low Grade Lymphoma (Neoplasm)

Role

preferred

Name

Lymphoid Neoplasm

Role

preferred

Name

Lymphoma, Diffuse

Role

preferred

Name

Lymphoma, Intermediate-Grade

Role

preferred

Name

Lymphoma, Lymphocytic, Intermediate

Role

preferred

Name

Lymphoma, Mixed-Cell

Role

preferred

Name

Lymphoma, Non-Hodgkin

Role

preferred

Name

Lymphoma, Undifferentiated

Role

preferred

Name

Malignant Neoplasm of Kidney

Role

preferred

Name

Primary Central Nervous System Lymphoma

Role

preferred

Name

Renal Carcinoma

Role

preferred

Name

Reticulosarcoma

Role

preferred

Name

T-CELL PROLYMPHOCYTIC LEUKEMIA, SOMATIC

Role

preferred

Name

Role

alias

Name

AT, COMPLEMENTATION GROUP A

Role

alias

Name

AT, COMPLEMENTATION GROUP C

Role

alias

Name

AT, COMPLEMENTATION GROUP D

Role

alias

Name

AT, COMPLEMENTATION GROUP E

Role

alias

Name

AT1

Role

alias

Name

ATA

Role

alias

Name

ATC

Role

alias

Name

ATD

Role

alias

Name

ATE

Role

alias

Name

African Lymphoma

Role

alias

Name

B Cell Lymphoma

Role

alias

Name

Role

alias

Name

Burkitt'S Tumour

Role

alias

Name

Burkitt'S Tumour Non-Hodgkin'S Lymphoma

Role

alias

Name

Cancer of Kidney

Role

alias

Name

Cancer of Lymphatic System

Role

alias

Name

Central Nervous System Lymphoma

Role

alias

Name

Kidney Cancer

Role

alias

Name

Kidney Neoplasms

Role

alias

Name

LCM

Role

alias

Name

LOUIS-BAR SYNDROME

Role

alias

Name

Lymphoma, B-Cell

Role

alias

Name

Lymphoma, High-Grade

Role

alias

Name

Lymphoma, Low-Grade

Role

alias

Name

Lymphoma, Lymphocytic, Diffuse, Poorly-Differentiated

Role

alias

Name

Lymphoma, Mantle-Cell

Role

alias

Name

Lymphosarcoma

Role

alias

Name

MCL

Role

alias

Name

Mantle Zone Lymphoma

Role

alias

Name

NHL

Role

alias

Name

NON-HODGKIN LYMPHOMA

Role

alias

Name

Neoplasia of The Kidneys

Role

alias

Name

Non-Hodgkin'S Lymphoma, Unspecified Type

Role

alias

Name

Primary Cns Lymphoma

Role

alias

Name

Renal Neoplasia

Role

alias

Name

Renal Neoplasm

Role

alias

Name

Renal Tumors

Role

alias

Name

Reticulum Cell Sarcoma

Role

alias

Name

Small Cleaved Cell (Diffuse)

Role

alias

Name

Small Cleaved Cell (Diffuse) Non-Hodgkin'S Lymphoma

Role

alias

Name

Small Non-cleaved Cell Lymphoma

Role

alias

Name

Undifferentiated (Diffuse)

Role

alias

Name

Undifferentiated (Diffuse) Non-Hodgkin'S Lymphoma

Role

alias

Cross References

Trusted external identifiers retained for this final record.

Hpo

HP:0002665HP:0009726HP:0012191HP:0012539HP:0030069HP:0030080

Herb

HBDIS000270HBDIS000414HBDIS001620HBDIS001810HBDIS001812HBDIS001814HBDIS001815HBDIS001816HBDIS003204HBDIS003205HBDIS003206HBDIS003210HBDIS003212HBDIS003215HBDIS007205HBDIS007623HBDIS008166HBDIS010451HBDIS010810HBDIS011530HBDIS014044HBDIS014080HBDIS014675HBDIS016042HBDIS018511HBDIS022095HBDIS027757HBDIS027764HBDIS027774

Me Sh

D001260D002051D007680D008223D008228D016393D020522

Omim

113970208900208910267730605027

Umls

C0004135C0006413C0022665C0024299C0024305C0079731C0079770C0334634C0555202C0919524C1859598C1876175

Icd10

C83.1C83.6C83.7C85.0C85.9G11.3

Med Dra

1000359410006595100535181006127510067184

Sym Map

SMDE01688SMDE02703SMDE02806SMDE04010SMDE04931SMDE06105SMDE06111SMDE06118SMDE06237SMDE10217SMDE10609SMDE10612SMDE10676

Do Class

DOID:14566DOID:630DOID:7

Dis Ge Net

C0004135C0006413C0022665C0024299C0024302C0024304C0024305C0024306C0079731C0079740C0079741C0079747C0079757C0079770C0280803C0334634C0343640C0598798C0740457C0751958C1368771C1378703C1629504C1843542C1876175C3714542C4721414C4721444C4721532

Orphanet

100116852416543

Umls Sty

T047T191

Hpo Class

HP:0000119HP:0001871HP:0002664

Me Sh Class

C01C04C10C12C13C14C15C16C18C20

Etcm Disease

Ataxia-TelangiectasiaBurkitt LymphomaLymphoma, Non-Hodgkin, FamilialMantle Cell Lymphoma

Tcmbank Disease

119061223913473147021486515678163611744818417200112238823102324124136256062566126451275312952129899300553110932054503050565071523754986176637073728203830

Itcmdb Generated

ITX-DISEASE-16917BF16189ITX-DISEASE-3842F2509028ITX-DISEASE-3F246F9E1950ITX-DISEASE-4197DBAEBAC3ITX-DISEASE-912FE85A78B7ITX-DISEASE-95D4CFB624ADITX-DISEASE-9C55A68C139DITX-DISEASE-BFCC12F83EEBITX-DISEASE-C2808B80B897ITX-DISEASE-E9364F2CDC9B

Attributes

Merged source attributes and domain-specific metadata.

Version

v1v1,v2v2

Suppress

Page Title

Disease Ataxia-Telangiectasia Details pageDisease Burkitt Lymphoma Details pageDisease Lymphoma, Non-Hodgkin, Familial Details pageDisease Mantle Cell Lymphoma Details page

Do Class Name

disease of anatomical entity; disease of cellular proliferationgenetic disease; disease of anatomical entity

Disease Type

diseasegroup

Hpo Class Name

Abnormality of the genitourinary system; NeoplasmNeoplasm; Abnormality of blood and blood-forming tissues

Do Disease Class

disease of anatomical entity; disease of cellular proliferationdisease of anatomical entity; genetic disease

Hpo Disease Class

Abnormality of blood and blood-forming tissues; NeoplasmNeoplasm; Abnormality of the genitourinary system

Umls Disease Type

Disease or SyndromeNeoplastic Process

Basic Information

Disease Name

Ataxia-Telangiectasia

Global Category

Fetal diseases;Genetic diseases;Rare diseases

Anatomical Category

Blood diseases;Ear diseases;Endocrine diseases;Eye diseases;Immune diseases;Neuronal diseases;Reproductive diseases;Skin diseases

Disease Name

Burkitt Lymphoma

Global Category

Cancer diseases;Genetic diseases;Rare diseases

Anatomical Category

Blood diseases

Disease Name

Lymphoma, Non-Hodgkin, Familial

Global Category

Cancer diseases;Genetic diseases;Rare diseases

Anatomical Category

Blood diseases;Immune diseases

Disease Name

Mantle Cell Lymphoma

Global Category

Cancer diseases;Rare diseases

Anatomical Category

Blood diseases;Immune diseases

Disease Definition

Ataxia with oculomotor apraxia type 1 (AOA1) is a rare autosomal recessive cerebellar ataxia (ARCA; see this term), characterized by progressive cerebellar ataxia associated with oculomotor apraxia, sAtaxia-telangiectasia is the association of severe combined immunodeficiency (affecting mainly the humoral immune response) with progressive cerebellar ataxia. It is characterised by neurological signBurkitt lymphoma is a rare form of malignant mature B-cell non-Hodgkin lymphoma.Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma (see this term) affecting B lymphocytes in the lymph nodes in a region called the ``mantle zone''.NCI2016_02D:This gene is involved in apoptosis, DNA repair and cell cycle regulation.NCI2016_NCI-GLOSS_1602D:A rare, inherited, progressive, degenerative disease of childhood that causes loss of muscle control, a weakened immune system, and an increased risk of cancer.|NCI2016_02D:Rare hereditary disease characterized by extreme sensitivity to ionizing radiation or radiomimetic drugs because of a defect in DNA repair. AT heterozygosity is estimated to occur in more than 2% of the U.S. population; heterozygotes exhibit increased radiation sensitivity and are at increased risk for several types of cancer. The normal version of the gene that is defective in AT appears to activate the p53-dependent response to DNA damage.|MSH2017_2016_08_12:An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).|MEDLINEPLUS_20151021:Ataxia-telangiectasia (AT) is a rare, inherited disease. It affects the nervous system, immune system, and other body systems. Symptoms appear in young children, usually before age 5. They include <ul> <li>Ataxia - trouble coordinating movements</li> <li>Poor balance </li> <li>Slurred speech</li> <li>Tiny, red spider veins, called telangiectasias, on the skin and eyes</li> <li>Lung infections</li> <li>Delayed physical and sexual development</li> </ul> People with AT have an increased risk of developing diabetes and cancers, particularly lymphoma and leukemia. Although it affects the brain, people with AT usually have normal or above normal intelligence. AT has no cure. Treatments might improve some symptoms. They include injections to strengthen the immune system, physical and speech therapy, and high-dose vitamin therapy. NIH: National Institute of Neurological Disorders and Stroke|CSP2006:inherited disease characterized by onset in early childhood of progressive cerebellar ataxia, oculocutaneous telangiectasis, and severe sinopulmonary infections.NCI2016_NCI-GLOSS_1602D:A type of cancer that forms in B cells (a type of immune system cell). B-cell lymphomas usually occur in adults and may be either indolent (slow-growing) or aggressive (fast-growing). There are many different types of B-cell lymphomas, and prognosis and treatment depend on the type and stage of cancer.|NCI2016_02D:The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003|MSH2017_2016_08_12:A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.|HPO2016_07_04:A type of lymphoma that originates in B-cells. [HPO:probinson]|CSP2006:any in a large group of nonHodgkin's lymphoma's characterized by malignant transformation of the B lymphocytes.NCI2016_NCI-GLOSS_1602D:An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that usually occurs in middle-aged or older adults. It is marked by small- to medium-size cancer cells that may be in the lymph nodes, spleen, bone marrow, blood, and gastrointestinal system.|NCI2016_02D:An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.|MSH2017_2016_08_12:A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).NCI2016_NICHD_1602D:A malignant neoplasm of the lymphatic system that is comprised of abnormal lymphocytes in the absence of Reed-Sternberg cells.|NCI2016_NCI-GLOSS_1602D:Any of a large group of cancers of lymphocytes (white blood cells). NHLs can occur at any age and are often marked by lymph nodes that are larger than normal, fever, and weight loss. There are many different types of NHL. These types can be divided into aggressive (fast-growing) and indolent (slow-growing) types, and they can be formed from either B-cells or T-cells. B-cell NHLs include Burkitt lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell NHLs include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. Lymphomas that occur after bone marrow or stem cell transplantation are usually B-cell NHLs. Prognosis and treatment depend on the stage and type of disease.|NCI2016_02D:Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage.|MSH2017_2016_08_12:Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.|HPO2016_07_04:A typer of lymphoma characterized microscopically by the absence of multinucleated Reed-Sternberg cells. [HPO:probinson]|CSP2006:characterized by malignant lymphomas; clinically similar to Hodgkin's disease, except that the lymphomas seen in this disease are initially more widespread; most common manifestation is painless enlargement of one or more peripheral lymph nodes.NCI2016_NICHD_1602D:A malignant neoplasm of the lymphatic system that is comprised of abnormal lymphocytes.|NCI2016_NCI-GLOSS_1602D:Cancer that begins in cells of the immune system. There are two basic categories of lymphomas. One kind is Hodgkin lymphoma, which is marked by the presence of a type of cell called the Reed-Sternberg cell. The other category is non-Hodgkin lymphomas, which includes a large, diverse group of cancers of immune system cells. Non-Hodgkin lymphomas can be further divided into cancers that have an indolent (slow-growing) course and those that have an aggressive (fast-growing) course. These subtypes behave and respond to treatment differently. Both Hodgkin and non-Hodgkin lymphomas can occur in children and adults, and prognosis and treatment depend on the stage and the type of cancer.|NCI2016_CDISC_1602D:A malignant neoplasm composed of lymphocytes of B- or T/NK-cell phenotype.|NCI2016_02D:A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas.|MSH2017_2016_08_12:A general term for various neoplastic diseases of the lymphoid tissue.|MEDLINEPLUS_20151021:Lymphoma is a cancer of a part of the immune system called the lymph system. There are many types of lymphoma. One type is <a href='https://www.nlm.nih.gov/medlineplus/hodgkindisease.html'>Hodgkin disease</a>. The rest are called non-Hodgkin lymphomas. Non-Hodgkin lymphomas begin when a type of white blood cell, called a T cell or B cell, becomes abnormal. The cell divides again and again, making more and more abnormal cells. These abnormal cells can spread to almost any other part of the body. Most of the time, doctors don't know why a person gets non-Hodgkin lymphoma. You are at increased risk if you have a weakened immune system or have certain types of infections. Non-Hodgkin lymphoma can cause many symptoms, such as <ul> <li>Swollen, painless lymph nodes in the neck, armpits or groin</li> <li>Unexplained weight loss </li> <li>Fever </li> <li>Soaking night sweats </li> <li>Coughing, trouble breathing or chest pain </li> <li>Weakness and tiredness that don't go away </li> <li>Pain, swelling or a feeling of fullness in the abdomen </li> </ul> Your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. Treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. Targeted therapy uses substances that attack cancer cells without harming normal cells. Biologic therapy boosts your body's own ability to fight cancer. If you don't have symptoms, you may not need treatment right away. This is called watchful waiting. NIH: National Cancer Institute|HPO2016_07_04:A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells. [HPO:probinson]|CSP2006:malignant (clonal) proliferation of B- or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites; general term for various neoplastic diseases of the lymphoid tissue.NCI2016_NICHD_1602D:Neoplasia located in the kidney.|NCI2016_02D:A benign or malignant neoplasm affecting the kidney. Representative examples of benign renal neoplasms include fibroma, lipoma, oncocytoma, and juxtaglomerular cell tumor. Representative examples of malignant renal neoplasms include renal cell carcinoma, renal pelvis carcinoma, Wilms tumor, rhabdoid tumor, sarcoma, and lymphoma.|MSH2017_2016_08_12:Tumors or cancers of the KIDNEY.|HPO2016_07_04:The presence of a neoplasm of the kidney. [HPO:probinson]|CSP2006:new abnormal tissue of the kidney that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.

Me Sh Disease Class

Cardiovascular Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Nutritional and Metabolic Diseases; Immune System DiseasesFemale Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; NeoplasmsImmune System Diseases; Infections; Neoplasms; Hemic and Lymphatic DiseasesImmune System Diseases; Neoplasms; Hemic and Lymphatic DiseasesNervous System Diseases; Immune System Diseases; Neoplasms; Hemic and Lymphatic Diseases

Dis Ge Net Disease Type

diseasegroup

Disease Class Name Me Sh

Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular DiseasesNeoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital DiseasesNeoplasms; Immune System Diseases; Hemic and Lymphatic DiseasesNeoplasms; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic DiseasesNeoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases

Umls Semantic Type Name

Disease or SyndromeNeoplastic Process