Clinical TrialID 804
Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease
NCT01271296
Addison Disease
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Record Fields
Scalar fields from the final clinical_trial record.
- Clinical Trial Id
- 804
- Evidence Id
- 804
- Core Evidence Id
- 804
- Source Clinical Trial Id
- 787
- Herb2 Clinical Trial Id
- HBCT000787
- Nct Id
- NCT01271296
- Title
- Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease
- Status
- Completed
- Phase
- Study Result
- No
- Study Condition
- Addison Disease
- Study Type
- Interventional
- Study Design
- Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
- Intervention
- DIETARY_SUPPLEMENT: Liquorice|DIETARY_SUPPLEMENT: Grapefruit Juice
- Intervention Allocation
- Randomized
- Intervention Model
- Crossover
- Intervention Mask
- Intervention Purpose
- Supportive_Care
- Gender
- All
- Age
- Adult, Older_Adult
- Enrollment
- 17
- Outcome Measure
- AUC Serum Cortisol - Levels of cortisol in serum during the first 2.6 hours after oral administration of cortisone acetate., The area under the curve (AUC) of cortisol is calculated based on serum time-series sampling (every 20 minutes for 2.6 h after oral administration of cortisone acetate). The AUCs obtained during liquorice and grapefruit juice intakes are compared to the baseline assessment (without these nutritional compounds). All other pharmacokinetic properties (primary and secondary outcome measures) are compared analogously., Outcome measures are assessed when all subjects have completed the study, approximately 1.5-2.0 years after study start.
- Sponsor Collaborator
- Haukeland University Hospital
- Funded By
- OTHER
- Location
- Haukeland University Hospital, Helse-Bergen HF, Bergen, 5020, Norway
- Other Id
- 3.2007.2620 (REK)|17775 (NSD)|07/5829 (SHdir)|3.2007.2620
- Start Date
- 2008-04
- Primary Completion Date
- 2009-01
- Completion Date
- 2009-01
- First Posted
- 2011-01-06
- Results First Posted
- Last Update Posted
- 2011-01-17
- Study Document
- Study Url
- https://clinicaltrials.gov/study/NCT01271296
- Title Cn
- Title En
- Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease
- Bilingual Status
- semi_complete