Clinical TrialID 794
Scavenging of Reactive Carbonyl Species by Apple Polyphenols in Human
NCT03911050
Human Health|Polyphenols|Pharmacokinetics
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Record Fields
Scalar fields from the final clinical_trial record.
- Clinical Trial Id
- 794
- Evidence Id
- 794
- Core Evidence Id
- 794
- Source Clinical Trial Id
- 778
- Herb2 Clinical Trial Id
- HBCT000778
- Nct Id
- NCT03911050
- Title
- Scavenging of Reactive Carbonyl Species by Apple Polyphenols in Human
- Status
- Completed
- Phase
- Study Result
- No
- Study Condition
- Human Health|Polyphenols|Pharmacokinetics
- Study Type
- Interventional
- Study Design
- Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
- Intervention
- DIETARY_SUPPLEMENT: Apple consumption|DIETARY_SUPPLEMENT: Control group
- Intervention Allocation
- Randomized
- Intervention Model
- Crossover
- Intervention Mask
- Double
- Intervention Purpose
- Treatment
- Gender
- All
- Age
- Adult, Older_Adult
- Enrollment
- 12
- Outcome Measure
- Change in urinary levels of reactive carbonyl species (RCS) adducts of apple polyphenols over 24 hours after one single dose of apple consumption, Liquid chromatography-tandem mass spectrometry will be utilized to assess RCS adducts of apple polyphenols in urine, 0-2, 2-4, 4-6, 6-9, 9-12, 12-24 hours post-dose|Change in plasma levels of RCS adducts of apple polyphenols over 24 hours after one single dose of apple consumption, Liquid chromatography-tandem mass spectrometry will be used to assess RCS adducts of apple polyphenols in plasma, 0, 0.5, 1, 1.5, 2, 4, 8, 24 hours post-dose|Change in levels of RCS adducts of apple polyphenols in feces over 48 hours after one single dose of apple consumption, Liquid chromatography-tandem mass spectrometry will be utilized to assess RCS adducts of apple polyphenols in fecal samples, 0, 24, 48 hours post-dose
- Sponsor Collaborator
- North Carolina Agriculture & Technical State University
- Funded By
- OTHER
- Location
- North Carolina Agriculture and Technical State University, Kannapolis, North Carolina, 28081, United States
- Other Id
- 18-0089
- Start Date
- 2018-11-26
- Primary Completion Date
- 2018-12-14
- Completion Date
- 2018-12-21
- First Posted
- 2019-04-10
- Results First Posted
- Last Update Posted
- 2019-04-10
- Study Document
- Study Url
- https://clinicaltrials.gov/study/NCT03911050
- Title Cn
- Title En
- Scavenging of Reactive Carbonyl Species by Apple Polyphenols in Human
- Bilingual Status
- semi_complete