Clinical TrialID 7629

A Randomized, Double-Blind, Placebo Controlled, Multicenter, Efficacy and Safety Trial of Single Cycle Tetrodotoxin in the Treatment of Chemotherapy Induced Neuropathic Pain

NCT05359133

Chemotherapy-induced Neuropathic Pain|Chemotherapy-induced Peripheral Neuropathy

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Record Fields

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Clinical Trial Id
7629
Evidence Id
7629
Core Evidence Id
7629
Source Clinical Trial Id
7626
Herb2 Clinical Trial Id
HBCT007626
Nct Id
NCT05359133
Title
A Randomized, Double-Blind, Placebo Controlled, Multicenter, Efficacy and Safety Trial of Single Cycle Tetrodotoxin in the Treatment of Chemotherapy Induced Neuropathic Pain
Status
Recruiting
Phase
Phase 2
Study Result
No
Study Condition
Chemotherapy-induced Neuropathic Pain|Chemotherapy-induced Peripheral Neuropathy
Study Type
Interventional
Study Design
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Intervention
DRUG: Tetrodotoxin|DRUG: Placebo
Intervention Allocation
Randomized
Intervention Model
Parallel
Intervention Mask
Quadruple
Intervention Purpose
Treatment
Gender
All
Age
Adult, Older_Adult
Enrollment
222
Outcome Measure
NPRS Pain reduction - at week 4, The Change from Baseline (average of Days -14 to -1) at Week 4 in average weekly NPRS scores in subjects treated with TTX compared to Placebo, At week 4
Sponsor Collaborator
Wex Pharmaceuticals Inc.
Funded By
INDUSTRY
Location
Syrentis Clinical Research, Santa Ana, California, 92705, United States|Providence Medical Foundation, Santa Rosa, California, 95403, United States|MEDSOL Clinical Research Center, Port Charlotte, Florida, 33952, United States|Care Access Research, Macon, Georgia, 31201, United States|Paradigm Clinical Research, Boise, Idaho, 83709, United States|Clinical Trials of SWLA, Lake Charles, Louisiana, 70601, United States|Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, 48201, United States|St Luke's Hospital of Kansas City, Kansas City, Missouri, 64111, United States|Care Access Research, Clifton, New Jersey, 07013, United States|ES Clinical Research Group, Garden City, New York, 11530, United States|SUNY Upstate Medical University, Syracuse, New York, 13210, United States|Oncology Specialists of Charlotte, Charlotte, North Carolina, 28207, United States|Oklahoma Cancer Specialists and Research Institute (OCSRI), Tulsa, Oklahoma, 74146, United States|Center for Oncology and Blood Disorders (COBD), Houston, Texas, 77030, United States|MD Anderson Cancer Center, Houston, Texas, 77030, United States
Other Id
TTX-CINP-202
Start Date
2022-04-19
Primary Completion Date
2025-12
Completion Date
2026-07
First Posted
2022-05-03
Results First Posted
Last Update Posted
2024-08-09
Study Document
Study Url
https://clinicaltrials.gov/study/NCT05359133
Title Cn
Title En
A Randomized, Double-Blind, Placebo Controlled, Multicenter, Efficacy and Safety Trial of Single Cycle Tetrodotoxin in the Treatment of Chemotherapy Induced Neuropathic Pain
Bilingual Status
semi_complete