Clinical TrialID 745
Anti-inflammatory Effect and Associated Mechanisms of Mango Consumption
NCT04726293
Overweight or Obesity|Healthy
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Record Fields
Scalar fields from the final clinical_trial record.
- Clinical Trial Id
- 745
- Evidence Id
- 745
- Core Evidence Id
- 745
- Source Clinical Trial Id
- 730
- Herb2 Clinical Trial Id
- HBCT000730
- Nct Id
- NCT04726293
- Title
- Anti-inflammatory Effect and Associated Mechanisms of Mango Consumption
- Status
- Active_Not_Recruiting
- Phase
- Study Result
- No
- Study Condition
- Overweight or Obesity|Healthy
- Study Type
- Interventional
- Study Design
- Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
- Intervention
- DIETARY_SUPPLEMENT: Mango|DIETARY_SUPPLEMENT: Control
- Intervention Allocation
- Randomized
- Intervention Model
- Parallel
- Intervention Mask
- Single
- Intervention Purpose
- Other
- Gender
- All
- Age
- Adult
- Enrollment
- 60
- Outcome Measure
- Characterize indices of systemic inflammation (IL-6) after 4 week intake of mango beverage compared to a control beverage, Assessments to address this aim will include analysis of systemic markers of inflammation (IL-6) in plasma, Baseline to 4 weeks|Characterize indices of systemic inflammation mechanism of action after 4 week intake of mango beverage compared to a control beverage, Assessments to address this aim via Toll like receptor, Nuclear factor erythroid 2-related factor 2, and nuclear factor kappa-light-chain-enhancer of activated B cells (TLR/Nrf2/NF-κB) activation in Monocytes isolated from peripheral blood., Baseline to 4 weeks|Characterize indices of systemic inflammation mechanism of action (Toll like receptor) after 4 week intake of mango beverage compared to a control beverage, Assessments to address this aim via Toll-like receptor, activation in Monocytes isolated from peripheral blood., Baseline to 4 weeks|Characterize indices of systemic inflammation mechanism of action (nuclear factor kappa-light-chain-enhancer of activated B cells ) after 4 week intake of mango beverage compared to a control beverage, Assessments to address this aim via nuclear factor kappa-light-chain-enhancer of activated B cells activation in Monocytes isolated from peripheral blood., Baseline to 4 weeks|Characterize indices of systemic inflammation mechanism of action (Nuclear factor erythroid 2-related factor 2) after 4 week intake of mango beverage compared to a control beverage, Assessments to address this aim via (Nuclear factor erythroid 2-related factor 2 activation in Monocytes isolated from peripheral blood., Baseline to 4 weeks|Characterize the gut microbiota in response to regular mango intake in OW/OB participants with chronic low grade inflammation., Fecal samples will be collected with standard collection kits and stored at -80°C until analysis. Metagenomic and transcriptomic analyses will be performed, Baseline to 4 weeks|Characterize indices of systemic inflammation (hs-CRP) after 4 week intake of mango beverage compared to a control beverage, Assessments to address this aim will include analysis of systemic markers of inflammation (hs-CRP) in plasma, Baseline to 4 weeks|Characterize indices of systemic inflammation (TNF-α) after 4 week intake of mango beverage compared to a control beverage, Assessments to address this aim will include analysis of systemic markers of inflammation (TNF-α) in plasma, Baseline to 4 weeks|Characterize indices of systemic inflammation (MCP-1) after 4 week intake of mango beverage compared to a control beverage, Assessments to address this aim will include analysis of systemic markers of inflammation (MCP-1) in plasma, Baseline to 4 weeks
- Sponsor Collaborator
- Clinical Nutrition Research Center, Illinois Institute of Technology|Food and Drug Administration (FDA)
- Funded By
- INDUSTRY
- Location
- Clinical Nutrition Research Center, Chicago, Illinois, 60616, United States
- Other Id
- IRB-2020-57
- Start Date
- 2021-02-22
- Primary Completion Date
- 2023-03-31
- Completion Date
- 2025-01-28
- First Posted
- 2021-01-27
- Results First Posted
- Last Update Posted
- 2024-08-09
- Study Document
- Study Url
- https://clinicaltrials.gov/study/NCT04726293
- Title Cn
- Title En
- Anti-inflammatory Effect and Associated Mechanisms of Mango Consumption
- Bilingual Status
- semi_complete