Clinical TrialID 7298
Acetate and Age-associated Arterial Dysfunction
NCT05424263
Aging|Vascular Stiffness|Vascular Dilation
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Record Fields
Scalar fields from the final clinical_trial record.
- Clinical Trial Id
- 7298
- Evidence Id
- 7298
- Core Evidence Id
- 7298
- Source Clinical Trial Id
- 7289
- Herb2 Clinical Trial Id
- HBCT007289
- Nct Id
- NCT05424263
- Title
- Acetate and Age-associated Arterial Dysfunction
- Status
- Recruiting
- Phase
- Phase 2
- Study Result
- No
- Study Condition
- Aging|Vascular Stiffness|Vascular Dilation
- Study Type
- Interventional
- Study Design
- Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
- Intervention
- DRUG: Calcium Acetate Oral Solution|DRUG: Calcium Carbonate Oral Suspension
- Intervention Allocation
- Randomized
- Intervention Model
- Parallel
- Intervention Mask
- Triple
- Intervention Purpose
- Treatment
- Gender
- All
- Age
- Adult, Older_Adult
- Enrollment
- 66
- Outcome Measure
- Change in Brachial Artery Flow-Mediated Dilation, Nitric oxide-mediated endothelium dependent dilation (vascular endothelial function) will be assessed at baseline and end-intervention by flow-mediated dilation of the brachial artery determined using high-resolution ultrasonography (Canon Xario 200) and analyzed with a commercially available software package (Vascular Analysis Tools, Medical Imaging Applications, LLC). Brachial artery flow-mediated dilation will be assessed by measuring brachial artery diameter and forearm blood flow at baseline and for 2 minutes following reactive hyperemia induced by 5 minutes of forearm blood flow occlusion (upper forearm cuff placement). Data will be expressed as a percent change in arterial diameter from pre-cuff inflation diameter, and then as a change in this % from baseline to end-intervention., 12 weeks
- Sponsor Collaborator
- University of Colorado, Denver
- Funded By
- OTHER
- Location
- University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, United States
- Other Id
- 22-0473
- Start Date
- 2022-09-29
- Primary Completion Date
- 2025-07-01
- Completion Date
- 2025-09-01
- First Posted
- 2022-06-21
- Results First Posted
- Last Update Posted
- 2024-03-15
- Study Document
- Study Url
- https://clinicaltrials.gov/study/NCT05424263
- Title Cn
- Title En
- Acetate and Age-associated Arterial Dysfunction
- Bilingual Status
- semi_complete