Clinical TrialID 6680
The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
NCT03746106
Vitamin B1 Deficiency|Thiamine Deficiency
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Record Fields
Scalar fields from the final clinical_trial record.
- Clinical Trial Id
- 6680
- Evidence Id
- 6680
- Core Evidence Id
- 6680
- Source Clinical Trial Id
- 6666
- Herb2 Clinical Trial Id
- HBCT006666
- Nct Id
- NCT03746106
- Title
- The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
- Status
- Completed
- Phase
- Phase 4
- Study Result
- No
- Study Condition
- Vitamin B1 Deficiency|Thiamine Deficiency
- Study Type
- Interventional
- Study Design
- Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
- Intervention
- DRUG: Trimethoprim|DRUG: Metformin|DIETARY_SUPPLEMENT: Vitamin B1
- Intervention Allocation
- Randomized
- Intervention Model
- Crossover
- Intervention Mask
- Intervention Purpose
- Basic_Science
- Gender
- All
- Age
- Adult, Older_Adult
- Enrollment
- 7
- Outcome Measure
- Area Under the Concentration-Time Curve (AUC 0-72h), Blood samples were obtained and plasma concentrations were determined using a validated high-pressure liquid chromatography method., As determined by blood/urine levels taken over the course of 2-3 cycles (each cycle is 3 days with a 5-14 day washout in between cycles)|Assess the effects of SLC19A3 inhibitors by Cmax, In Parts 1 and 2, assess the effects of SLC19A3 inhibitors on the absorption and distribution of thiamine as measured by the change in maximum concentration (Cmax) between the combination arm(s) and single agent arm., As determined by blood/urine levels taken over the course of 2-3 cycles (each cycle is 3 days with a 5-14 day washout in between cycles)
- Sponsor Collaborator
- University of California, San Francisco|Tufts University|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|University of California, Davis
- Funded By
- OTHER
- Location
- Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Massachusetts, 02111, United States
- Other Id
- 13060|5R01DK108722-02
- Start Date
- 2019-01-28
- Primary Completion Date
- 2023-08-10
- Completion Date
- 2023-08-10
- First Posted
- 2018-11-19
- Results First Posted
- Last Update Posted
- 2023-08-14
- Study Document
- Study Url
- https://clinicaltrials.gov/study/NCT03746106
- Title Cn
- Title En
- The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
- Bilingual Status
- semi_complete