Clinical TrialID 5446
Effect of Serum LDL Cholesterol Concentration on Pancreatic Insulin Secretion
NCT04314167
Hypercholesterolemia|Insulin Resistance|Insulin Secretion
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Record Fields
Scalar fields from the final clinical_trial record.
- Clinical Trial Id
- 5446
- Evidence Id
- 5446
- Core Evidence Id
- 5446
- Source Clinical Trial Id
- 5432
- Herb2 Clinical Trial Id
- HBCT005432
- Nct Id
- NCT04314167
- Title
- Effect of Serum LDL Cholesterol Concentration on Pancreatic Insulin Secretion
- Status
- Terminated
- Phase
- Study Result
- No
- Study Condition
- Hypercholesterolemia|Insulin Resistance|Insulin Secretion
- Study Type
- Interventional
- Study Design
- Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
- Intervention
- DRUG: Lowering cholesterol concentrations by PCSK-9 inhibitor
- Intervention Allocation
- Intervention Model
- Single_Group
- Intervention Mask
- Intervention Purpose
- Basic_Science
- Gender
- All
- Age
- Adult, Older_Adult
- Enrollment
- 9
- Outcome Measure
- Change in insulin secretion., Effect of lowering LDL cholesterol levels on insulins secretion.This will be quantified in half of the patients by a hyperglycemic clamp and in the other half by a 75 g oral glucose tolerance test (randomized assignment)., before and after 12 weeks of treatment with a PCSK9-inhibitor.
- Sponsor Collaborator
- University Hospital Tuebingen
- Funded By
- OTHER
- Location
- University of Tuebingen, Department of Internal Medicine IV, Tuebingen, 72076, Germany
- Other Id
- 045/2020BO2
- Start Date
- 2020-07-28
- Primary Completion Date
- 2024-03-01
- Completion Date
- 2024-03-01
- First Posted
- 2020-03-19
- Results First Posted
- Last Update Posted
- 2024-05-16
- Study Document
- Study Url
- https://clinicaltrials.gov/study/NCT04314167
- Title Cn
- Title En
- Effect of Serum LDL Cholesterol Concentration on Pancreatic Insulin Secretion
- Bilingual Status
- semi_complete