Clinical TrialID 4973
Effect of Uridine on GABA and High Energy Phosphate Levels in Healthy Volunteers
NCT01261260
Healthy Male Subjects
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Record Fields
Scalar fields from the final clinical_trial record.
- Clinical Trial Id
- 4973
- Evidence Id
- 4973
- Core Evidence Id
- 4973
- Source Clinical Trial Id
- 4953
- Herb2 Clinical Trial Id
- HBCT004953
- Nct Id
- NCT01261260
- Title
- Effect of Uridine on GABA and High Energy Phosphate Levels in Healthy Volunteers
- Status
- Completed
- Phase
- Phase 1
- Study Result
- No
- Study Condition
- Healthy Male Subjects
- Study Type
- Interventional
- Study Design
- Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
- Intervention
- DRUG: Uridine
- Intervention Allocation
- Randomized
- Intervention Model
- Parallel
- Intervention Mask
- Triple
- Intervention Purpose
- Gender
- Male
- Age
- Adult
- Enrollment
- 33
- Outcome Measure
- Using MRI and MRS, after uridine administration an increase in brain GABA and NTP levels will be seen and increases in GABA and NTP will be correlated, This choice of time period will allow a determination of time course to efficacy between the acute and extended ranges, and further, because therapeutic dosage levels of uridine have yet to be established, in this and future studies we hope to determine the optimal dosage at which uridine increases brain GABA and ß-NTP levels., after 7 days of treatment
- Sponsor Collaborator
- Mclean Hospital|National Institute of Mental Health (NIMH)
- Funded By
- OTHER
- Location
- McLean Hospital, Belmont, Massachusetts, 02478, United States
- Other Id
- 2005-P-002083-McLean|2R01MH058681-04A2
- Start Date
- 2006-11
- Primary Completion Date
- 2008-08
- Completion Date
- 2008-08
- First Posted
- 2010-12-16
- Results First Posted
- Last Update Posted
- 2010-12-16
- Study Document
- Study Url
- https://clinicaltrials.gov/study/NCT01261260
- Title Cn
- Title En
- Effect of Uridine on GABA and High Energy Phosphate Levels in Healthy Volunteers
- Bilingual Status
- semi_complete