Clinical TrialID 2538
Effect of 4 Weeks of Citrulline and Glutathione Supplementation on Arterial Function
NCT04672447
Menopause|Cardiovascular Risk Factor
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Record Fields
Scalar fields from the final clinical_trial record.
- Clinical Trial Id
- 2538
- Evidence Id
- 2538
- Core Evidence Id
- 2538
- Source Clinical Trial Id
- 2518
- Herb2 Clinical Trial Id
- HBCT002518
- Nct Id
- NCT04672447
- Title
- Effect of 4 Weeks of Citrulline and Glutathione Supplementation on Arterial Function
- Status
- Completed
- Phase
- Study Result
- No
- Study Condition
- Menopause|Cardiovascular Risk Factor
- Study Type
- Interventional
- Study Design
- Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
- Intervention
- DIETARY_SUPPLEMENT: L-Citrulline|DIETARY_SUPPLEMENT: L-Citrulline|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Glutathione
- Intervention Allocation
- Randomized
- Intervention Model
- Parallel
- Intervention Mask
- Double
- Intervention Purpose
- Basic_Science
- Gender
- Female
- Age
- Adult, Older_Adult
- Enrollment
- 39
- Outcome Measure
- Change in endothelial function, Endothelial function will be measured before and after the intervention using brachial artery flow mediated dilation at rest, blood flow measured in the brachial artery during handgrip exercise, and blood flow in the common femoral artery during passive leg movement. All measurements performed using doppler ultrasound., 4 weeks|Change in arterial stiffness, Arterial stiffness will be assessed through measurement of pulse-wave velocity of the carotid-femoral, carotid radial, carotid-ankle and femoral ankle arterial segments before and after the 4 week interventions., 4 weeks|Blood pressure control during the cold pressor test, Blood pressure will be measured during the cold pressor test before and after the 4 weeks., 4 weeks|L-Arginine bioavailability, Plasma levels of arginine will be measured before and after the 4 week intervention., 4 weeks
- Sponsor Collaborator
- Texas Tech University|Kyowa Hakko Bio Co., Ltd.
- Funded By
- OTHER
- Location
- TTU Kinesiology and Sport Management Building, Lubbock, Texas, 79409, United States
- Other Id
- 20-0152
- Start Date
- 2020-07-01
- Primary Completion Date
- 2022-04-27
- Completion Date
- 2022-04-27
- First Posted
- 2020-12-17
- Results First Posted
- Last Update Posted
- 2022-10-20
- Study Document
- Study Url
- https://clinicaltrials.gov/study/NCT04672447
- Title Cn
- Title En
- Effect of 4 Weeks of Citrulline and Glutathione Supplementation on Arterial Function
- Bilingual Status
- semi_complete