Clinical TrialID 117
The Impact of Broad Bean Hull on Blood Glucose Control and Gut Health
NCT05252013
Healthy|Overweight
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Record Fields
Scalar fields from the final clinical_trial record.
- Clinical Trial Id
- 117
- Evidence Id
- 117
- Core Evidence Id
- 117
- Source Clinical Trial Id
- 112
- Herb2 Clinical Trial Id
- HBCT000112
- Nct Id
- NCT05252013
- Title
- The Impact of Broad Bean Hull on Blood Glucose Control and Gut Health
- Status
- Completed
- Phase
- Study Result
- No
- Study Condition
- Healthy|Overweight
- Study Type
- Interventional
- Study Design
- Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
- Intervention
- OTHER: Experimental: Bean Hull Bread|OTHER: Experimental: Plain Bread
- Intervention Allocation
- Randomized
- Intervention Model
- Crossover
- Intervention Mask
- Intervention Purpose
- Basic_Science
- Gender
- All
- Age
- Adult, Older_Adult
- Enrollment
- 9
- Outcome Measure
- Plasma key bioactive metabolites following the control and bean hull bread consumption, The intervention visit will involve a test meal to be consumed by subjects attending the Human Nutrition Unit (HNU) in the morning, following an overnight fast. They will be provided with a meal, which will be consumed within 15 minutes and blood samples will be collected postprandial over 4 hours. For both the control and test diet, plasma markers of the principal metabolites produced by the phenylpropanoid pathway and products of protein and carbohydrate metabolism will be measured over 4-hour interval and compared with baseline., over 4 hours|Plasma key bioactive metabolites following the control and bean hull bread consumption, The intervention visit will involve a test meal to be consumed by subjects attending the Human Nutrition Unit (HNU) in the morning, following an overnight fast. They will be provided with a meal, which will be consumed within 15 minutes and blood samples will be collected on the day. The participants will be provided with plain/bean hull bread rolls to be consumed on day 1 (intervention day), days 2 and 3. Fasted blood samples will be measured on day 4. The principal metabolites produced by the phenylpropanoid pathway and products of protein and carbohydrate metabolism following the 3 days consumption of the test and control diet will be measured in fasted plasma of day 4. These metabolites will be compared with the baseline (day 1) and between diets (day 4 vs day 4)., Day 4|Faecal key bioactive metabolites excretion, The intervention visit will involve a test meal to be consumed by subjects attending the Human Nutrition Unit (HNU) in the morning, following an overnight fast. They will be provided with a meal, consumed within 15 minutes. Participants will also consume the plain/bean hull bread for days 1, 2, 3. A second faecal sample will be collected on day 4 to assess participants' gut bioavailability of key nutrients and bioactive following the chronic consumption of the plain/bean hull bread rolls. The principal metabolites produced by the phenylpropanoid pathway and products of protein and carbohydrate metabolism following the 3 days consumption of the test and control diet will be measured in faecal samples of day 4. These metabolites will be compared with the baseline (day 1) and between diets (day 4 vs day 4)., Day 4 (post intervention)|Determine the effects of consumption bean hull fortified bread on Ghrelin levels, To investigate the effect of bean hull bread on ghrelin. The intervention visit will involve a test meal to be consumed by subjects attending the Human Nutrition Unit (HNU) in the morning, following an overnight fast. They will be provided with a meal, which will be consumed within 15 minutes and blood samples will be collected on the day. Ghrelin levels will be measured over 4 hours following the consumption of the plain/bean hull bread rolls., over 4 hours|Determine the effects of consumption bean hull fortified bread on GLP-1 levels, To investigate the effect of bean hull bread on the hormone GLP-1. The intervention visit will involve a test meal to be consumed by subjects attending the Human Nutrition Unit (HNU) in the morning, following an overnight fast. They will be provided with a meal, which will be consumed within 15 minutes and blood samples will be collected on the day. GLP-1 levels will be measured over 4 hours following the consumption of the plain/bean hull bread rolls., over 4 hours|Determine the effects of consumption bean hull fortified bread on glucagon, To investigate the effect of bean hull bread on the hormone glucagon. The intervention visit will involve a test meal to be consumed by subjects attending the Human Nutrition Unit (HNU) in the morning, following an overnight fast. They will be provided with a meal, which will be consumed within 15 minutes and blood samples will be collected on the day. Glucagon levels will be over 4 hours following the consumption of the plain/bean hull bread rolls., over 4 hours|Determine the effects of consumption bean hull fortified bread on PYY, To investigate the effect of bean hull bread on the hormone PYY. The intervention visit will involve a test meal to be consumed by subjects attending the Human Nutrition Unit (HNU) in the morning, following an overnight fast. They will be provided with a meal, which will be consumed within 15 minutes and blood samples will be collected on the day. PYY levels will be measured over 4 hours following the consumption of the plain/bean hull bread rolls., over 4 hours
- Sponsor Collaborator
- University of Aberdeen
- Funded By
- OTHER
- Location
- University of Aberdeen, Rowett Institute, Aberdeen, Aberdeen City, AB10 6JW, United Kingdom
- Other Id
- 4667
- Start Date
- 2019-01-31
- Primary Completion Date
- 2020-03-31
- Completion Date
- 2020-03-31
- First Posted
- 2022-02-23
- Results First Posted
- Last Update Posted
- 2022-02-23
- Study Document
- Study Url
- https://clinicaltrials.gov/study/NCT05252013
- Title Cn
- Title En
- The Impact of Broad Bean Hull on Blood Glucose Control and Gut Health
- Bilingual Status
- semi_complete